Dinotefuran is a new furanicotinyl insecticide which represents the third generation of neonicotinoid group. Dinotefuran, which was developed by Mitsui Chemicals, Inc., was registered in Japan April 24, 2002 and the registration has been submitted to the Environment Protection Agency (EPA) in the USA. Dinotefuran was granted Organophosphorus Alternative and Reduced Risk Status by the EPA.
Physical & Chemicals Properties
Common Name: Dinotefuran (ISO name)
Chemical Name: (RS)-1-methyl-2-nitro-3-(tetrahydro-3-furylmethyl) guanidine
Melting Point: 107.5° C
Water Solubility: 39.83 g/
Acute Toxicity for Mammalian (Technical)
Oral (Rat, Mouse) LD50 ≥2,000 mg/kg Dermal (Rat) LD50 >2,000 mg/kg
Avian & Aquatic Toxicity (Technical)
Japanese quail LD50 ≥2,000 mg/kg Mallard duck LD50 >997.9 mg/kg/day Carp LD50 (96hr) >1,000 ppm Daphnia LD50 (48hr) >1,000 ppm
Skin Irritation (Technical)
Long Term Health Effects (Technical)
Dinotefuran is not a mutagen, neurotoxin or reproductive toxin.
Dinotefuran is highly toxic to honeybees and silkworms.
Environmental Fate (Half-lives)
Hydrolysis Stable Photolysis on Soil 46 days Aerobic Soil Metabolism 52 days Field Dissipation 22 to 68 days
Mode of Action
Dinotefuran acts through contact and ingestion and results in the cessation of feeding within several hours of contact and death shortly after. Dinotefuran does not inhibit cholinesterase or interfere with sodium channels. Therefore, its mode of action is different from those of organophosphate, carbamate, and pyrethroid compounds. It appears that Dinotefuran acts as an agonist of insect nicotinic acetylcholine receptors, but it is postulated that Dinotefuran affects the nicotinic acetylcholine binding in a mode that differs from other neonicotinoid insecticides. It is reported that Dinotefuran was highly active on a certain silverleaf whitefly strain which developed resistance against imidacloprid.
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