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Dinotefuran

Dinotefuran is a new furanicotinyl insecticide which represents the third generation of neonicotinoid group. Dinotefuran, which was developed by Mitsui Chemicals, Inc., was registered in Japan April 24, 2002 and the registration has been submitted to the Environment Protection Agency (EPA) in the USA. Dinotefuran was granted Organophosphorus Alternative and Reduced Risk Status by the EPA.

Physical & Chemicals Properties

Code: MTI-446
Common Name: Dinotefuran (ISO name)
Chemical Name: (RS)-1-methyl-2-nitro-3-(tetrahydro-3-furylmethyl) guanidine

Chemical Structure: image

Melting Point: 107.5° C
Water Solubility: 39.83 g/l

 

Toxicology

Acute Toxicity for Mammalian (Technical)

Oral (Rat, Mouse) LD50 ≥2,000 mg/kg
Dermal (Rat) LD50 >2,000 mg/kg

Avian & Aquatic Toxicity (Technical)


Japanese quail LD50 ≥2,000 mg/kg
Mallard duck LD50 >997.9 mg/kg/day
Carp LD50 (96hr) >1,000 ppm
Daphnia LD50 (48hr) >1,000 ppm

Skin Irritation (Technical)
      Slightly Irritating

Long Term Health Effects (Technical)
      Dinotefuran is not a mutagen, neurotoxin or reproductive toxin.

Ecological Effect
      Dinotefuran is highly toxic to honeybees and silkworms.

Environmental Fate (Half-lives)

Hydrolysis Stable
Photolysis on Soil 46 days
Aerobic Soil Metabolism 52 days
Field Dissipation 22 to 68 days

Mode of Action

Dinotefuran acts through contact and ingestion and results in the cessation of feeding within several hours of contact and death shortly after. Dinotefuran does not inhibit cholinesterase or interfere with sodium channels. Therefore, its mode of action is different from those of organophosphate, carbamate, and pyrethroid compounds. It appears that Dinotefuran acts as an agonist of insect nicotinic acetylcholine receptors, but it is postulated that Dinotefuran affects the nicotinic acetylcholine binding in a mode that differs from other neonicotinoid insecticides. It is reported that Dinotefuran was highly active on a certain silverleaf whitefly strain which developed resistance against imidacloprid.

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Application Method

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The information contained in this website is, to the best of our knowledge, accurate and reliable, but all suggestions are made without warranty, either express or implied. The values relevant to properties or the like of the product stated herein were obtained using field test specimens prepared at official organizations in some countries and are not assumed to be identical to values obtained on the finished product manufactured by our customers and on our finished product tested by our customers in a different condition. Nothing herein shall be construed as permission or as recommendation for uses which infringe valid patents or as extending a license under valid patents. Because the conditions and methods of use on the part of our customers are beyond our control, Mitsui Chemicals, Inc. disclaims any liability incurred in connection with the use of our products.
 
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